ROGERS, June 29, 2014 (AFP) - Lewis, who attended the University of Arkansas in nearby Fayetteville, collected her 11th career victory and third of the season with a 12-under-par 201 in the 54-hole event.
She also won the North Texas LPGA Shootout and ShopRite LPGA Classic, but she admitted this one was tougher.
"It's so hard to play here," said Lewis, who was the focus of exuberant support from the crowd. "I can tell you I was more nervous today than I was at the US Open last week. That's just how much this place means to me."
New Zealand teenager Lydia Ko also fired a final-round 65 to jump into a share of second place with US veteran Cristie Kerr (67) and American Angela Stanford (67) on 202.
South Korea's Ryu So-Yeon closed with a 69 for 203, one stroke in front of Chella Choi, of South Korea, and Norway's Suzann Pettersen.
American Michelle Wie, who was coming off her first major title at the US Women's Open at Pinehurst, held a two-stroke lead going into the final round but tripped to a two-over 73 to fall into a share of eighth place on eight-under 205.
Seventy-two players had to complete the second round on Sunday morning after storms halted play on Saturday, although Wie was already in the clubhouse with the lead on Saturday night.
Leading final-round scores on Sunday in the 54-hole LPGA Northwest Arkansas Championship (USA unless stated, par-71):
201 - Stacy Lewis 70-66-65
202 - Lydia Ko (NZL) 69-68-65, Cristie Kerr 69-66-67, Angela Stanford 68-67-67
203 - Ryu So-Yeon (KOR) 67-67-69
204 - Chella Choi (KOR) 70-65-69, Suzann Pettersen (NOR) 68-67-69
205 - Julieta Granada 72-68-65, Meena Lee (KOR) 70-70-65, Jennifer Rosales (PHI) 67-71-67, Karine Icher (FRA) 72-65-68, Lee Mi-Hyang (KOR) 71-65-69, Mina Harigae 70-66-69, Michelle Wie 66-66-73
206 - Park Hee-Young (KOR) 69-70-67, Park In-Bee (KOR) 69-69-68, Choi Na-Yeon (KOR) 68-69-69, Alejandra Llaneza (MEX) 66-70-70
207 - Jennifer Johnson 69-72-66, Hur Mi-Jung (KOR) 72-68-67, Pornanong Phatlum (THA) 67-72-68, Line Vedel (DEN) 68-68-71
208 - Jennifer Song 72-70-66, Morgan Pressel 71-70-67, Han Hee-Won (KOR) 69-72-67, Brooke Pancake 71-69-68, Dori Carter 69-71-68, Mo Martin 68-71-69, Caroline Hedwall (SWE) 67-72-69, Gerina Piller 67-69-72