NETHERLANDS, 12 Sept 2016, (AFP) - The 30-year-old produced a dazzling display of iron play and long-range putting to deny Austrian Bernd Wiesberger by three shots.
The pair went blow for blow for much of the fourth round but three birdies in his final five holes helped Luiten to a 19-under-par total of 265.
Luiten was the first Dutch player to win his home Open twice since it joined the European Tour in 1972 - following his win in 2013 - and makes him a five-time winner on Tour.
"The first one was special but this one is very special," he said.
"To have the Dutch people behind me all week and to be able to stand here with the trophy in my hands is very special.
"It was one of those days where everything I looked at went in the hole.
"These are the kind of days that make it all worth getting out of bed for."
This was his first win for almost two years and reward for a brilliantly consistent 2016 so far that saw him come into the week with eight top tens, including two runner-up finishes, and represent the Netherlands at the Olympic men's golf competition in Rio.
South Korea's An Byeong-hun was third at 13 under after matching Austria's Wiesberger with a 65, a shot ahead of Spaniard Alejandro Canizares, English duo Ben Evans and David Horsey and Australia's Scott Hend.
England's Chris Hanson and Frenchman Mike Lorenzo-Vera were then at 11 under, a shot ahead of Tommy Fleetwood, Scott Jamieson, Simon Khan, Mikko Korhonen, Lee Soo-min and Brandon Stone.
Leading fourth-round scores on Sunday from the Dutch Open at Spijk (Gbr & Irl unless stated, par 71):
265 - Joost Luiten (NED) 69 64 69 63
268 - Bernd Wiesberger (AUT) 66 66 71 65
271 - Byeong-Hun An (KOR) 66 72 68 65
272 - Ben Evans 65 69 68 70, Scott Hend (AUS) 67 68 64 73, David Horsey 67 68 67 70, Alejandro Canizares (ESP) 67 67 70 68
273 - Mike Lorenzo-Vera (FRA) 68 68 69 68, Chris Hanson 66 71 67 69